There is no definitive answer to this question, as there are a multitude of factors that contribute to a Shopify store's overall profitability. However, some key factors to consider include the store's niche, the quality of its products, its marketing strategy, and its customer base.
In general, stores that sell high-quality products in a niche market tend to be the most profitable. This is because they can charge a premium price for their products, and customers are willing to pay more for items that they perceive to be of higher quality. Additionally, stores with a well-executed marketing strategy are typically more profitable than those without one. This is because a good marketing strategy will reach the right customer base and help to increase conversion rates.
Ultimately, the best way to determine which Shopify stores are the most profitable is to look at a variety of different factors and make an informed decision. However, if you are just starting out, it may be best to choose a store that sells products in a niche market, as they tend to be more profitable overall.