There is not really a straightforward answer to this question since it depends on a lot of factors, such as your specific network configuration and what kind of wireless driver you are using. However, in general, it is possible to unload and reload the wireless driver using network manager.
If you are using a Network Manager-compatible wireless driver, you can use the "nmcli" command to unload and reload the driver. For example, to unload the driver for the "wlp4s0" interface, you would use the following command:
nmcli con down id wlp4s0
To reload the driver, you would use the following command:
nmcli con up id wlp4s0
You can also use the "ifdown" and "ifup" commands to unload and reload the wireless driver, respectively. For example, to unload the driver for the "wlp4s0" interface, you would use the following command:
ifdown wlp4s0
To reload the driver, you would use the following command:
ifup wlp4s0
Which command you use will depend on your specific network configuration and what kind of wireless driver you are using.