There is no simple answer to this question since it depends on a number of factors, including the type of products you sell, your target market, how well you market your store, etc. However, in general, Shopify can be a very profitable platform for businesses of all sizes.
For example, Shopify's average order value is $80, which is significantly higher than the average order value of $36 for all other ecommerce platforms (source: https://www.startups.com/library/expert-advice/ecommerce/shopify-vs-other-ecommerce-platforms). This means that, on average, Shopify stores make more money per order than stores on other platforms.
Additionally, Shopify offers a number of features and tools that can help you increase your profits, such as abandoned cart recovery, professional themes, discount codes, etc.
Overall, whether or not a Shopify store is profitable depends on a number of factors. However, in general, Shopify can be a very successful platform for businesses of all sizes.