No, digital versions of PC games are not region locked on Amazon in the U.S. for PC. Amazon.com sells digital versions of PC games directly, and there are no regional restrictions on purchasing and playing these games. However, it's important to note that some PC games may have regional restrictions for certain content or features. It's always best to check the product page for the game in question before making a purchase.
It's also important to bear in mind that while Amazon.com may not region lock the games, third-party sellers may have different policies in place. Before making a purchase, customers should always make sure to check the seller's policies and terms of sale.
Finally, any downloadable content associated with a game may have its own regional restrictions. Again, customers should always check the product page for a game before making a purchase.
Hope this helps!